Methanocarba derivatives of pseudoribose that inhibit adenosine kinase

摘要

Adenosine kinase inhibitors, including pharmaceutical compositions containing the adenosine kinase inhibitors, and their use for preventing epilepsy and its progression in patients. The adenosine kinase inhibitors have the formula:; where the moieties J and K, considered in combination, are —CH₂—, or K and L, considered in combination, are —CH₂—. The R¹ moiety can be —NH₂, C₁-C₆ alkyl, C₁-C₆ alkoxy, or C₁-C₆ hydroxyalkyl. The R² and R³ moieties are each independently C₁-C₆ alkyl. The R⁴ moiety is hydrogen or C₁-C₆ alkyl. The R⁵ and R⁶ moieties are each independently C₆-C₁₂ aryl, C₃-C₈ cycloalkyl, or C₃-C₈ heteroaryl, that is optionally further substituted.