STRUCTURE AND FUNCTION OF THE SALICYCLIC ACID BINDING SITES ON HUMAN HMGB1 AND METHODS OF USE THEREOF FOR THE RATIONAL DESIGN OF BOTH SALICYCLIC ACID DERIVATIVES AND OTHER AGENTS THAT ALTER ANIMAL AND PLANT HMGBS ACTIVITIES

摘要

Compositions and methods for identifying agents which 1) mimic salicyclic acid binding to human, animal and plant high mobility group box proteins or 2) alter activities of these HMGBs by binding in or around their salicyclic acid-binding sites and agents so identified are disclosed.