MUTANT IMMUNOGLOBULIN K CHAIN VARIABLE REGION-BINDING PEPTIDE

摘要

A first immunoglobulin κ chain variable region-binding peptide includes an amino acid sequence of SEQ ID NO: 21 with substitution of one or more amino acid residues at the 15^th position, the 16^th position, the 17^th position or the 18^th position, wherein an acid dissociation pH thereof is shifted to a neutral side. A second immunoglobulin κ chain variable region-binding peptide further includes deletion, substitution and/or addition of 1-20 amino acid residues at positions other than the 15^th position, the 16^th position, the 17^th position and the 18^th position. A third immunoglobulin κ chain variable region-binding peptide includes an amino acid sequence with a sequence identity of 80% or more to the amino acid sequence of the first immunoglobulin κ chain variable region-binding peptide.