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INTERLEUKIN-2 EXPRESSION CONSTRUCT USING HUMAN SERIUM ALBUMIN
INTERLEUKIN-2 EXPRESSION CONSTRUCT USING HUMAN SERIUM ALBUMIN
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机译:人血清白蛋白表达白介素2的构建
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摘要
The present invention relates to an interleukin-2 expression construct for yeast, comprising a methanol oxidase (MOX) promoter; a human serum albumin gene or a fragment thereof; and an interleukin-2 (IL-2) gene, and to a yeast comprising the expression construct. The interleukin-2 expression construct for yeast according to the present invention makes it possible to produce an expressed and secreted fusion protein of human serum albumin (HSA) and interleukin-2 at low costs and easily separate recombinant interleukin-2 from the fusion protein. Thus, the interleukin-2 expression construct for yeast may be effectively used to produce a large amount of recombinant interleukin-2 with high purity.
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