USE OF CLINICAL KNOWLEDGE TO IMPROVE USE OF NEXT GENERATION SEQUENCING

摘要

A method (100) of ensuring optimal use of next generation sequencing (NGS) in complex therapy decision making is disclosed herein. Such a method may include: identifying (105) an infected patient eligible for NGS; determining (110) a patient care trajectory for the infected patient, where this trajectory is determined from database records of physical contact by the infected patient with a healthcare resource; sequencing (115) an isolate from the infected patient; while sequencing, identifying (120) additional patients at risk of infection, determining (125) overlap in the patient care trajectory of the infected patient and patient care trajectories of additional patients, and determining (130) a risk of infection to the additional patients based on this overlap and clinical data points for the additional patients; determining (135) an updated risk of transmission to the additional patients; and causing (140) a computing device to render output of the updated risk of transmission to the one or more additional patients.