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5-acylsulfanyl-histidine compounds as precursors of the corresponding 5-sulfanylhistidines and their disulfides

机译:5-酰基硫烷基-组氨酸化合物作为相应的5-硫烷基组氨酸及其二硫化物的前体

摘要

The invention relates to a compound of the 5-acylsulfanyl-histidine type and the derivatives thereof, of general formula (I), wherein R1 to R3=H, alkyl, especially CH3; R4=H, alkyl, especially CH3, alkyle(C=0), substituted alkyl (C═O), aryl (C═O); β-alanyl (H2NCH2CH2 (C═O); α-amino-acyl; R5=alkyl, especially methyl, phenyl. The invention also relates to the use of said compound for producing compounds of the 5-sulfanyl-histidine type and the derivatives thereof, in addition to corresponding disulfides; and to the various methods for the production thereof.
机译:本发明涉及一种通式为(Ⅰ)的5-酰基硫烷基-组氨酸类型的化合物及其衍生物,其中R 1至R 3 = H,烷基,尤其是CH 3。 R4 = H,烷基,尤其是CH3,烷基(C = 0),取代的烷基(C = O),芳基(C = O); β-丙氨酰基(H 2 NCH 2 CH 2(C = O);α-氨基-酰基; R 5 =烷基,尤其是甲基苯基)。本发明还涉及所述化合物在制备5-硫烷基-组氨酸类型的化合物中的用途及其衍生物。除相应的二硫化物外,还包括其;以及其生产的各种方法。

著录项

  • 公开/公告号US9926300B2

    专利类型

  • 公开/公告日2018-03-27

    原文格式PDF

  • 申请/专利权人 TETRAHEDRON;

    申请/专利号US201515314628

  • 发明设计人 SYLVAIN DAUNAY;IRENE ERDELMEIER;

    申请日2015-05-29

  • 分类号C07D233/84;C07D403/12;

  • 国家 US

  • 入库时间 2022-08-21 12:56:50

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