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Materials and methods for targeting therapeutic compositions to gut-associated lymphoid tissue (GALT)
Materials and methods for targeting therapeutic compositions to gut-associated lymphoid tissue (GALT)
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机译:用于将治疗组合物靶向肠道相关淋巴组织(GALT)的材料和方法
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摘要
The present invention provides novel, long-acting nanoformulated drugs and targeted drug delivery methods, and uses thereof. In one embodiment, the nanoformulated drug is a retroviral drug. In one embodiment, the nanoformulated composition comprises a nanocarrier with one or more incorporated drugs. In an exemplary embodiment, the drug is efavirenz (EFV). In a further embodiment, the nanocarrier is associated with an agent for targeting microfold cells (M-cells). In a specific embodiment, the targeting agent binds to an M-cell marker known as glycoprotein 2 (GP2). Via this mechanism, the nanodrug is targeted toward GALT.
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