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ANTI-HIV DUAL SPECIFICITY ANTIBODIES AND METHODS OF HIV TREATMENT
ANTI-HIV DUAL SPECIFICITY ANTIBODIES AND METHODS OF HIV TREATMENT
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机译:抗HIV双重特异性抗体和HIV治疗方法
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摘要
Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The DVD Igs may be asymmetric and may have more variable domains on either the light chain or the heavy chain of the Igs. The DVD Igs may have specificity for gp41 and gp120. Therapies are provided using DVD Igs to neutralize HIV viral loads.
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机译:提供了双可变域免疫球蛋白(DVD Igs),其能够四价结合至人免疫缺陷病毒(HIV)的双特异性位点。 DVD Ig可能是不对称的,并且在Ig的轻链或重链上可能具有更多的可变域。 DVD Ig对gp41和gp120具有特异性。提供了使用DVD Ig来中和HIV病毒载量的疗法。
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