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Multifunctional new Mohist education combination

机译:多功能新的墨家教育组合

摘要

1. Characteristic 1: multifunctional immune components, including 13 different dosa protein mixtures, plus a physiologically acceptable vehicle, Each of them contains a kind of vesicular polygonal polymer with different serum types of single cell Streptococcus polymer, which combines a carrier protein and vesicular polygonal polymer, and is prepared together with serum types 1, 3, 4, 5, 6a, 6F, 7F, 9V, 14, 18C, 19A, 19F and 23F, wherein the transport protein is crm8321; 83298327y, wherein the polymer is polymer; By reducing ammonia. Requirement 3: immune ingredients meeting requirement 2,Adyuvante is an aluminum adyuvante. Requirement 6: the immune composition determined according to any one of 1-4 requirements characterized by vaccine application; requirement 8: the immune composition determined according to any one of 1-4 requirements for infant and young child vaccination, The vaccination plan is at 2,4,6 and 12-15 months old Requirement 9: immune composition that meets any one of the 1-4 requirements for vaccination of juveniles and adults. 1. Claim 10: a syringe made of 1, 3, 4, 5, 6a, 6b, 7F, 9V, 14, 18C, 19A, 19F and 23F single dose of polycystal Spirulina fluid which is incorporated into crm8321;where each 0.5 ml dose is formulated to contain 2.2 mg of each saccharide, except 6B which is 4 mg, approximately 29 mg of the CRM₁₉₇ carrier protein,0.125 mg of elemental aluminum adjuvant (0.5 mg of aluminum phosphate) and buffer of sodium chloride and sodium succinate as excipients. Claim 13: A process for preparing a multivalent immunogenic composition, comprising 13 different polysaccharide-protein conjugates, together with a physiologically acceptable vehicle, where each of the conjugates comprises a different capsular polysaccharide conjugated to a CMR₁₉₇ carrier protein,The polyurethanes were prepared from the serum of pneomone streptock 1, 3, 4, 5, 6a, 6b, 7F, 9V, 14, 18C, 19A, 19F and 23F. The single polyurethanes were purified by centrifugation, precipitation, exudation and chromatography; 2. Purified polymerases are chemically active to produce anesthetics that can react with cmr83218329 protein;once activated, each capsular polysaccharide is individually conjugated to the CRM₁₉₇ transporter protein to form a glycoconjugate; the individual glycoconjugates are purified and compounded to formulate the immunogenic composition.
机译:1.特征1:多功能免疫成分,包括13种不同的dosa蛋白混合物,以及生理上可接受的媒介物,它们各自包含一种具有不同血清类型的单细胞链球菌聚合物的囊泡状多聚体,其结合了载体蛋白和囊泡状多聚体聚合物,与血清类型1、3、4、5、6a,6F,7F,9V,14、18C,19A,19F和23F一起制备,其中转运蛋白为crm8321; 83298327y,其中聚合物是聚合物;通过减少氨气。要求3:满足要求的免疫成分2,Adyuvante是铝的Adyuvante。要求6:根据1-4要求中任一项确定的免疫组合物,其特征在于疫苗的应用;要求8:根据1-4项婴幼儿疫苗要求中的任何一项确定的免疫成分,疫苗接种计划应在2、4、6和12-15个月大时进行要求9:满足以下任一要求的免疫成分1-4少年和成人疫苗接种要求。 1.权利要求10:由1、3、4、5、6a,6b,7F,9V,14、18C,19A,19F和23F单剂量的多囊螺旋藻液体制成的注射器,其合并入crm8321;其中每0.5 ml剂量配制为包含2.2 mg的每种糖,除了6B(4 mg),约29 mg的CRM₁₉₇载体蛋白,0.125 mg的元素铝佐剂(0.5 mg的磷酸铝)以及氯化钠和琥珀酸钠的缓冲液作为赋形剂。 13,一种制备多价免疫原性组合物的方法,该组合物包含13种不同的多糖-蛋白质结合物,以及生理上可接受的媒介物,其中每种结合物均包含与CMR-载体蛋白结合的不同荚膜多糖。 1、3、4、5、6a,6b,7F,9V,14、18C,19A,19F和23F。通过离心,沉淀,渗出和色谱法纯化单个聚氨酯。 2.纯化的聚合酶具有化学活性,可产生可与cmr83218329蛋白反应的麻醉剂;一旦活化,每个荚膜多糖分别与CRM₁₉₇转运蛋白结合,形成糖结合物;将各个糖缀合物纯化并复合以配制免疫原性组合物。

著录项

  • 公开/公告号AR107018A2

    专利类型

  • 公开/公告日2018-03-14

    原文格式PDF

  • 申请/专利权人 WYETH;

    申请/专利号AR2016P103764

  • 发明设计人

    申请日2016-12-07

  • 分类号A61K39/09;A61K39/39;A61K47/50;A61P11;A61P37/04;

  • 国家 AR

  • 入库时间 2022-08-21 12:54:16

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