Heterocyclic chemokine receptor binding compounds, their uses in the treatment of receptor-related chemokine conditions, inflammatory, allergic and autoimmune diseases, as well as pharmaceutical compositions including them

摘要

"enhanced efficacy heterocyclic chemokine receptor binding compounds". This invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, where two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains n and optionally contains additional rings. The compounds bind to chemokine receptors, including cxcr4 and ccr5, and demonstrate protective effects against target cell infection by a human immunodeficiency virus (hiv).