methods for expressing an antigenic molecule or a portion thereof and generating an immune response, pharmaceutical composition, cell or cell population, uses of a cell population and antigenic molecule, antigenic molecule, photosensitizing agent and cytokine, product, and kit

摘要

The present invention provides a method for expressing an antigenic molecule or a portion thereof on the surface of a cell using a photochemical internalization method in which a cytokine, preferably gm-csf, is used to enhance the method. The method can be used to stimulate an immune response and for various therapeutic or prophylactic methods. Pharmaceutical compositions or kits comprising components for use in the method, cells produced by the method and their use in therapy and prophylaxis also form aspects of the invention.