REVERSION OF THE EFFECTS OF TUMOR MICRO-ENVIRONMENT USING CHEMICAL CYTOKIN RECEPTORS

摘要

Disclosed are compositions and methods related to rendering ineffective Thl T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Thl immunostimulatory/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IE 10, IE 13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.