首页> 外国专利> METHOD FOR PREDICTING DEVELOPMENT OF DIABETES TYPE 2 BY ANALYSIS OF N-GLYCAN FROM BLOOD PLASMA OF HEALTHY PEOPLE

METHOD FOR PREDICTING DEVELOPMENT OF DIABETES TYPE 2 BY ANALYSIS OF N-GLYCAN FROM BLOOD PLASMA OF HEALTHY PEOPLE

机译：通过健康人血液血浆中的N-甘氨酸分析预测2型糖尿病的发生的方法

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摘要

Predmetni izum odnosi se na predviđanje razvoja dijabetesa tipa 2 putem kvantitativne analize N-glikana iz krvne plazme zdrave osobe, koji omogućava utvrđivanja je li ispitana osoba spada u rizičnu skupinu za razvoj dijabetesa tipa 2 u budućnosti. Dobiveni kvantitativni udjeli svih analiziranih glikana koriste se kao ulazni parametri modela F:BR/ F(GP1, GP2, …, GPX; D, S) BR/gdje su X, D i S parametri modela F:BR/ X = ukupan broj analiziranih N-glikana;BR/ D = broj godina starosti ispitivane osobe;BR/ S = spol ispitivane osobe; muški= 1, ženski= 0; BR/Konstante modela F(GP1, GP2, …, GPX; D, S) dobivene su statističkom obradom podataka i modeliranjem nad određenom populacijom zahvaćenom analitikom. Dobiveni rezultat F za neku osobu se uspoređuje s pragom T, koji je prethodno statistički određen, i koji definira prag povećanog rizika za razvoj dijabetesa tipa 2 (T2D) u budućnosti.

机译：本发明涉及通过从健康人的血浆中对N-聚糖进行定量分析来预测2型糖尿病的发展，这允许确定受试者是否属于将来发展为2型糖尿病的危险组。所获得的所有分析聚糖的定量份额都用作模型F的输入参数：
F（GP1，GP2，…，GPX; D，S）
其中X，D和S是模型F的参数：
X =分析的N-聚糖总数，
D =受试者的年龄，
S =受试者的性别;男= 1，女= 0;
模型F常数（GP1，GP2，…，GPX，D，S）是通过对受分析人员影响的特定人群进行统计数据处理和建模而获得的。将获得的一个人的F得分与阈值T进行比较，该阈值T是先前通过统计方法确定的，并且定义了将来患上2型糖尿病（T2D）的风险增加的阈值。

著录项

公开/公告号HRP20160662A2

专利类型
公开/公告日2017-12-15

原文格式PDF
申请/专利权人 GENOS D.O.O.;
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申请/专利号HR2016P000662
发明设计人 GORNIK OLGA;GORNIK IVAN;VUČKOVIĆ FRANO;LAUC GORDAN;
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申请日2016-06-13
分类号G06F19;G01N33/48;G01N33/50;
国家 HR
入库时间 2022-08-21 12:52:43

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Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). 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