Binding proteins.

摘要

Referring to any Protein Binding Protein of inducible co Stimulator (ICOS) or t lymphocyte antigen binding portion thereof which comprises one or more cdrh1 as discussed in sec.ID no: 1; cdrh2 as SEC ID no: 2; cdrh3 as SEC ID no: 3; cdrl1 as SEC ID no: 4; cdrl2 as SEC ID no: 5 and / or cdrl3 as SEC ID no: 6 or a direct equivalent of each corIn which a direct equivalent to no more than two amino acid substitutions in the CDR.This Protein is an agonist for Human icos and induces complement Binding Protein, these Defendants or Antigen binding portions thereof,Are able to activate T Lymphocyte When placed in contact with the T Lymphocyte; stimulate t-cell Proliferation when in contact with the T Lymphocyte and / or induce proProduction of cytokines when in contact with said T Lymphocyte. It also relates to a Pharmaceutical composition.To be useful in the treatment of cancer, infectious disease and / or septicemia in a human being in need.