Imidazopirazinonas PDE1 inhibitors

摘要

Refers to a compound of formula I wherein n is 0 OR 1, Q is 0 OR 1; r1 is selected from the group consisting of benzyl, indanilo,Heteroarilos indoline and 5 members; all of which can be substituted with a Halogen Substituent selected from the group consisting of C1 and C3 alkyl -,Among others; R2 is selected from the group consisting of hydrogen, C1 to C8 - linear or branched alkyl, phenyl, among others; R3 is selected from the group consisting of hydrogen, halogen,C1 - C5 alkyl; R4 is Hydrogen.These compounds are inhibitors of phosphodiesterase 1 (PDE1 Enzymes), regulating the intracellular Signalling Pathways, preferably in the nervous system.Or enhance the levels of the second Messengers Camp / cGMP. It also relates to pharmaceutical composition.These compounds are useful in the treatment of neurodegenerative Disorders and Psychiatric Disorders.