Method for asymmetric reduction of prochiral ketones

摘要

the object of the application is the way prochiralnych asymmetric reduction of ketones, characterized by that in the environment without solvent, ketone of formula 1.where: r1 and r2 means independently group: aromatic or polyetherdiamine, including alkilowu0105 or allilowu0105, possibly a a substituent: aliphatic, alkoksylowym, arylowym, alkoksylowym,aryloksylowym, nitrowym or halide or combination thereof, is subjected to reaction with trietoksysilanem in the presence of a catalyst in amounts of from 0.05 to 0.3 mol%.a complex zn2 + with ligandem diaminowym l, n, n '- dipodstawionu0105 (r, r) - 1,2 - difenyloetylo - 1,2 - diaminu0105, advantageously selected among compounds of the formula, l1, l2, l3.with alcohol of formula 2.