a study of the prevalence and genetic polymorphism of epstein barr virus in gastric adenocarcinomes south of tunisia.

摘要

the present invention relates to, in the first place, the determination of the prevalence of gastric cancer associated with ebv, cgaebv) in the south of tunisia and, secondly, the genotypic profile of souchare detected in gastric tumors).in fact,certain types of gastric cancer (gc) were associated with epstein barr virus (cgaebv) and viral presence has been highlighted by the large noncoding small rna expression formsthe "ebers.on the other hand, in the cgaebv, viral gene expression, corresponding to the latency of type i, characterized by the expression of ebna 1, eber genes.lmp2a (latent membrane protein 2a) and written work.to determine the prevalence and genetic polymorphism of the ebv virus in 81 patients with gastric adenocarcinoma.we used the method of in situ hybridization using an oligonucleotide probe against the ebers, coupled with fluorescein for identification of functionfor ebv pcr, pcr-rflp and sequencing for genotyping of viral strains.