A method for preparing aliphatic esters beta-functionalized

摘要

Method for preparing carboxylic esters ß-functionalized according to formula (I) ** ** Formula wherein R represents an alkyl group having 1 to 8 carbon atoms, R 'represents a hydrogen atom or an alkyl radical 1 to 8 carbon atoms, and n represents zero or a number from 1 to 20, and X represents a Ph-R '' where R '' represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or R '' 'group' - N-R '' ', where R' '' and R '' independently represent branched or cyclic having 1 to 8 carbon atoms or form linear alkyl or, together with the atom nitrogen to which they are attached a pyrrolyl, pyrrolinyl or pyrrolidinyl, characterized by reacting in a single step an unsaturated ester according to the general formula (II) ** ** formula wherein n, R and R 'have the same meaning as in formula (I), in the presence of a second compound selected from a boron compound selected from the group comprising PhB (OH) 2, PhB (pi n), ester PhBMIDA, PhBF3K, KB (4-CIC6H4) 4, NaB (2-naphthyl) 4, NaB (4-tolyl) 4 and KB (2-thienyl) 4 and sodium tetraphenylborate or an amine R '' ' -NH-R '' (IV) where R '' 'and R' 'have the same meaning as above in the presence of a rhodium-containing catalyst selected from (i) Rh (acac) (COD), [Rh (OH) (COD)] 2 and [Rh (Cl) (COD)] 2 together with (ii) a ligand Biphephos or P (Oalil) 3 in molar amounts of (i): (ii) or 2: 1 1: 2 and preferably 1: 1, in an atmosphere without oxygen at temperatures between 80 and 120 ° C in a solvent.