N-acylthioureas and N-acylureas inhibitory of the signaling pathway of Hedgehog proteins

摘要

Use of compounds of the following formula (I): ** Formula ** in which: - R1, R2 and R3, identical or different and independently of each other, represent a hydrogen or halogen atom, a hydroxyl radical , an alkyl, perfluoroalkyl, alkoxy, alkylthio, nitrile group, a substituted alkoxy, or a fused heterocycle obtained from two of the adjacent radicals R1, R2, and R3, which can form, together with the carbon atoms of the phenyl ring to which they are attached, a fused heterocycle, - X represents a sulfur or oxygen atom, - Y represents a substituted or unsubstituted mono- or polycyclic heteroaryl group, a -NH- (C = O) -R6 group, - (C = O) -NH-R6 or -NH- (C = O) -NH-R6, where R6 represents an unsubstituted aryl group; an aryl group comprising one or more substituents chosen from a halogen atom and an alkyl, alkoxy or mono- or dialkylamino radical; a mono- or polycyclic heteroaryl group; a linear or branched alkyl radical; a saturated or unsaturated mono- or polycyclic hydrocarbon group; - R4 and R5, identical or different and independently of each other, represent a hydrogen or halogen atom, an alkoxy, alkylthio, alkyl, perfluoroalkyl, nitrile or nitro group, for the manufacture of a medicament for the treatment of associated tumors to an overactivation of the Hedgehog protein signaling pathway, these tumors being chosen from tumors of the nervous tissue (medulloblastomas, primary neuroectodermal tumors, glioblastomas, meningiomas and oligodendrogliomas), skin tumors (basal cell carcinomas, trichoepitheliomas), tissue tumors muscle and bone (rhabdomyosarcomas, osteosarcomas) or tumors of other tissues (kidney, gallbladder) or neurodegenerative diseases chosen from plaque sclerosis or motor neuron disease.