Glucagon superfamily peptides that show nuclear hormone receptor activity

摘要

Compound comprising the structure Q-L-Y; wherein Q is a glucagon superfamily peptide that has agonist activity at the glucagon receptor, the GIP receptor, the GLP-1 receptor, or a combination thereof; And it is a steroid that activates a nuclear hormone receptor of Type I, in which Y has a molecular weight of up to about 1,000 daltons; and L is a linker group or link.