Causal therapy of diseases or conditions associated with CNS or SNP demyelination

摘要

2-Oxopyrrolidine compound for use in the causal treatment or prevention of a disease or condition associated with demyelination of the central nervous system (CNS) or peripheral nervous system (SNP) in a mammal while maintaining the integrity of myelination of cells axonic, the 2-oxopyrrolidine compound having a general formula I: ** (See formula) ** in which R is hydrogen, hydroxyl or aminomethyl; R 'is hydrogen or piperidinocarbonyl group; R "is hydrogen, aminocarbonylalkyl optionally N-substituted with a dialkyl (C1-C4) -amino-alkyl (C2-C4), anilinocarbonylalkyl group optionally mono or disubstituted in the benzene ring with methyl, methoxy or halogen; benzyl, optionally mono or disubstituted in the benzene ring with methyl, methoxy or halogen, wherein one or two of R, R 'and R "is hydrogen; with the conditions that when R 'is different from hydrogen, then R and R "are both hydrogen, and when R is different from hydrogen, then R' is hydrogen, or a pharmaceutically acceptable salt thereof; and in that the disease or The state associated with demyelination of the central nervous system (CNS) or peripheral nervous system (SNP) is multiple sclerosis (MS).