Method and kits for determining the status of tuberculosis infection

摘要

In vitro method for determining the State of infection of tuberculosis (TB) in an individualComprising: (i) provide a sample comprising T lymphocytes; (ii) Exposing the sample of (i) one or more antigens of TB; (iii) identify t-lymphocytes in the sample that are CD4 positive(VO) and secrete TNF alpha and IFN gamma secreting; or (b) secreting ifn-y without secrete TNF alpha (iv); (iii) identify cells that are also negative and CCR7 Disorders; and optionally (V) calculate the cu00e9luThe identified in (iv) as a percentage of the identified in (iii), in which the identification of cells in (iv) and / or cell percentage calculated in (V) is correlated with thisOJ of TB infection in the individual stages, and (iii) and (iv) may be performed sequentially or in parallel.