Bilaterally substituted tricyclic compounds for the treatment of human immunodeficiency virus type 1 (HIV-1) infection and other diseases

摘要

Compound of Formula (I) ** Formula ** or a pharmaceutical salt, ester, solvate or hydrate thereof. wherein A, B and C are benzene, R1 and R2 are in bilateral disubstitution 1,3 with respect to each other in benzene A and in meta relative to the carbon atom of A bonded to benzene B; and are independently selected from optionally substituted aminomethyl, aminoethyl, and aminopropyl; R3 and R4 are in bilateral disubstitution 1,3 with respect to each other in benzene B and in ortho relative to the carbon atom of B bonded to benzene A; and are independently selected from hydrogen, (C1-C6) alkylamide, (C1-C6) alkyl ester, hydroxyalkyl (C1-C6), halo (C1-C6) alkyl, (C1-C6) alkoxyalkyl, (C1-C8) alkyl , with the proviso that at least one of R3 and R4 is not hydrogen; R5 and R6 are in bilateral disubstitution 1,3 with respect to each other in benzene C and in ortho relative to the carbon atom of C bonded to benzene B; and are independently selected from optionally substituted aminomethyl, aminoethyl, and aminopropyl; R7 and R8 are independently selected from hydrogen, halogen, hydroxyl, (C1-C10) alkoxy, (C1-C10) alkylamine, (C1-C10) alkylguanidine, (C1-C10) alkylamide, (C1-C10) alkyl ester, hydroxyalkyl (C1-C10), alkoxyalkyl (C1-C10), haloalkyl (C1-C10), alkyl (C1-C10), aryl alkoxy and aryl ester