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Compositions and methods to affect the movement of pollutants, body fluids or other entities and / or affect other physiological conditions

机译:影响污染物,体液或其他实体运动和/或影响其他生理状况的成分和方法

摘要

Composition comprising self-assembling peptidomimetic compounds, comprising alternate hydrophobic and hydrophilic residues, in which the hydrophilic residues alternate between positively charged and negatively charged residues, in which the self-assembling peptidomimetic compounds are selected from the group consisting of oligoureas with N, N ', oligopyrrolinones, oxazolidin-2-ones, azathides, azapeptides, β-peptides, γ-peptides, δ-peptides and copolymers of α-peptides, β-peptides, γ-peptides and δ-peptides, in the that the peptides have a length within the range of 6-64 amino acid residues for use in a method to inhibit the movement of a body fluid and / or contaminant on or in an animal when administered to a site that needs it, in that the self-assembling peptidomimetic compounds are capable, after interaction with at least one ionic species present in or on an animal, of forming a structure that inhibits the movement of a body fluid and / or contaminant on or in the animal.
机译:包含自组装拟肽化合物的组合物,其包含交替的疏水和亲水残基,其中亲水性残基在带正电和负电荷的残基之间交替,其中自组装拟肽化合物选自具有N,N'的寡聚体,寡吡咯烷酮,恶唑烷-2-酮,氮杂肽,氮杂肽,β肽,γ肽,δ肽以及α肽,β肽,γ肽和δ肽的共聚物,因为这些肽具有a长度在6-64个氨基酸残基范围内,用于在向需要其的部位给药时抑制体液和/或污染物在动物身上或动物中运动的方法,其中自组装拟肽化合物与动物中或动物上存在的至少一种离子物质相互作用后,能够形成抑制体液和/或动物或动物体内的污染物运动的结构。

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