Methods and compositions for treating and detecting misfolded SOD1 mediated Diseases

摘要

A composition for use in the treatment of Amyotrophic Lateral Sclerosis (ALS),Such a composition comprising a pharmaceutically acceptable vehicle and an agent selected from: (1) exogenous isolated an Antibody or fragment thereof that selectively binds to an epitope ESPThe Disease ecu00edfico (DSE) selected from: (i) dlgkggneestktgnags (SEQ ID no: 2) or cdlgkggneestktgnags (SEQ ID no: 11)(ii) cikglteglhgf (SEQ ID no: 14) or ikglteglhgf (SEQ ID no: 5); and (iii) glhgfhvh (SEQ ID no: 7); and / or (iv) an epitope specific disease of one of I)(ii) or (iii) comprising one or more amino acids or oxidized, nitrated, and / or (2) an immunogen comprising a Peptide consisting of the amino acid sequence of any of SEQ ID no: 2, 5, 7,11 14, including up to 50 residue Peptide immunogen of SOD1, or (2) comprising one or more amino acids or oxidized, nitrated.