Chiral synthesis of N- {3,4-difluoro-2 - (2-fluoro-4-iodophenyl) amino -6-methoxyphenyl} -1- 2,3-dihydroxy-propyl cyclopropanesulfonamides

摘要

A compound selected from: 1 - {[(4S) -2,2-dimethyl-1,3-dioxolan-4-yl] methyl} cyclopropanesulfonyl bromide (S) -10-Br: ** Formula ** 1 bromide - {[(4R) -2,2-dimethyl-1,3-dioxolan-4-yl] methyl} cyclopropanesulfonyl (R) -10-Br: ** Formula ** 1 - {[(4S) -2,2 -dimethyl-1,3-dioxolan-4-yl] methyl} potassium cyclopropanesulfonate (S) -7 ': ** Formula ** 1- {[(4R) -2,2-dimethyl-1,3-dioxolan- Potassium (R) -7 '4-yl] methyl} cyclopropanesulfonate: ** Formula ** 1 - {[(4S) -2,2-dimethyl-1,3-dioxolan-4-yl] methyl} butyl cyclopropanesulfonate (S) -6: ** Formula ** 1 - {[(4R) -2,2-dimethyl-1,3-dioxolan-4-yl] methyl} butyl cyclopropanesulfonate (R) -6: ** Formula * * 1 - [(2S) -2,3-dihydroxypropyl] butyl cyclopropanesulfonate (S) -5: ** Formula ** 1 - [(2R) -2,3-dihydroxypropyl] butyl cyclopropanesulfonate (R) -5: ** Formula ** 1 - [(2S) -oxyran-2-ylmethyl] butyl cyclopropanesulfonate (S) -4: ** Formula ** 1 - [(2R) -oxyran-2-ylmethyl] butyl cyclopropanesulfonate (R ) -4: ** Formula ** 1 - [(2S) -3-Chloro-2-hydroxypropyl] cyclopropanesulfonate bu butyl (S) -3: ** Formula ** 1 - [(2R) -3-chloro-2-hydroxypropyl] butyl cyclopropanesulfonate (R) -3: ** Formula ** 1 - [(2S) -3- {[tert-butyl (dimethyl) silyl] oxy} -2-hydroxypropyl] butyl (S) -9a cyclopropanesulfonate: ** Formula ** 1 - [(2R) -3 - {[tert-butyl (dimethyl) silyl] oxy} -2-hydroxypropyl] butyl (R) -9a cyclopropanesulfonate: ** Formula ** 1 - [(2S) -2-hydroxy-3- (tetrahydro-2H-pyran-2-yloxy) propyl] cyclopropane sulfonate butyl (S) -9b: ** Formula ** 1- [(2R) -2-hydroxy-3- (tetrahydro-2H-pyran-2-yloxy) propyl] butyl cyclopropane sulfonate (R) -9b: ** Formula**