CELL CULTURE SYSTEM, PROCESS FOR THE PRODUCTION THEREOF, AND THE USE THEREOF IN PRECLINICAL INVESTIGATION

摘要

The invention relates to a cell culture system, particularly for the preclinical testing of active ingredients, comprising a first and a second compartment. The active ingredients are in communication with each other via a separation layer that is permeable for cellularly secretable substances between the first and second compartments, wherein the first compartment comprises a syntopic culture with tissue cells and immune cells and the second compartment has a culture with blood cells. The invention further relates to a corresponding method and to a kit and uses for the preclinical testing of active ingredients.