MODIFIED PROTOZOAN EXPRESSING AT LEAST TWO VARIABLE SURFACE PROTEINS (VSP), A VACCINE COMPRISING IT AND PROCEDURES, USES, AND METHODS THEREOF

摘要

Modified protozoa parasitescomprising simultaneous expression on its surfaceof at least two variable surface proteins(VSP). The modified protozoa may also simultaneouslyexpress the complete repertoire ofvariable surface proteins. Protozoa show reducedexpression of Dicer, RNA-dependantRNA-polymerase (RdRP) enzymes or both,wherein the RdRP gene and/or the Dicer genehas been silenced. The protozoan may be anyprotozoan showing an antigenic variationmechanism.