MONOCLONAL ANTIBODIES FOR THE IDENTIFICATION AND CHARACTERIZATION OF ANTIESTROGENS AND SELECTIVE ESTROGEN RECEPTOR MODULATORS

摘要

A number of monoclonal antibodies is provided having a specific affinity forthe ligand bindingdomain of human estrogen receptor alpha (ER.alpha. LBD) bound with an agonistligand or anantagonist ligand. The monoclonal antibodies have a specific affinity forepitopes containedwithin amino acids 297-554. A method of screening Selective Estrogen ReceptorModulators(SERMs) is also provided, as is a method of identifying estrogenic compounds.