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FORMULATIONS FOR MITIGATING OPIOID OVERDOSE AND METHODS OF MAKING AND USING THE SAME
FORMULATIONS FOR MITIGATING OPIOID OVERDOSE AND METHODS OF MAKING AND USING THE SAME
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机译:缓解阿片类药物过量的配方及其制造和使用方法
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摘要
The presently disclosed subject matter is directed to opioid antagonistformulationsfor use in mitigating opioid abuse and/or overdose in a subject. Particularly,thedisclosed formulation comprises an immediate release opioid antagonist coupledwithan extended release opioid antagonist. The disclosed opioid antagonistsattenuate theactivity of an opioid agonist and thus prevent or reverse the adverse effects.of theagonist. Particularly, the immediate release component allows for immediateavailabilityof the opioid antagonist to provide fast onset treatment, while the extendedreleasecomponent allows continued release of the opioid antagonist to furthermitigate theopioid overdose. Thus, the disclosed formulation advantageously provides afast-onsetopioid antagonist in addition to a slow-release opioid antagonist, lasting upto 48 hourspost administration.
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