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MODELING MIRNA INDUCED SILENCING IN BREAST CANCER WITH PARADIGM
MODELING MIRNA INDUCED SILENCING IN BREAST CANCER WITH PARADIGM
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机译:使用paraparaGM对乳腺癌中miRNA诱导的沉默进行建模
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摘要
A probabilistic graphical pathway model is modified to include miRNA regulation by adding RISC as a regulatory factor. Most preferably, the pathway model is built using factor graphs, and the RISC includes DICER, TARBP2, and AGO2 or AGO1/3/4. So constructed pathway models can be used to infer RISC activity, which can be associated with various clinically relevant parameters to build various predictors or diagnostic tests.
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