MIRNA AND USE THEREOF IN TREATMENT OF METABOLIC DISEASE

摘要

A miRNA and use thereof in the preparation of medicaments for treating metabolic diseases. The miRNA is miR-149-3p, and the miR-149-3p comprises a combination of one or more of (a)-(f) as follows: (a) a pri-miRNA of miR-149-3p; (b) a pre-miRNA of miR-149-3p; (c) a mature miRNA of miR-149-3p; (d) a modified miR-149-3p derivative; (e) a miRNA having a core sequence as shown in SEQ ID NO：1, a length of 18-26nt and the same or substantially the same function as miR-149-3p; and (f) a modified derivative of (e) above. Compared with the traditional therapeutic medicaments, the miRNA can inhibit the occurrence and development of metabolic diseases by enhancing the insulin sensitivity of the body, reducing the abnormal accumulation of triglycerides in the liver and reducing the deposition of lipid plaques in the blood vessel, and can be used in the preparation of medicaments for preventing and treating metabolic diseases and in the diagnosis and treatment of metabolic diseases.