ACTIVATION OF P2X7 RECEPTORS WITH NON-BZBZ ADENOSINE TRIPHOSPHATE DERIVATIVES

摘要

Compositions and methods are presently disclosed that provide improved efficiacy for the treatment of cancer. In particular, 3-O-ribose monoester derivatives of adenosine triphosphate are observed to have vastly superior efficiacy over a previously reported compond, 3,5 benzoylbenzoyl adenosine triphosphate. These novel compounds have been shown to increase calcium channel activation mediated by the P2X7 receptor thereby resulting in increase apoptosis of cancer cells, either malignant or benign.