An object of the present invention is to provide an eyedrops which can maintain an excellent preservative effect for a long period of time without substantially containing a cationic preservative and a nonionic surfactant, and a method for maintaining an eyedrops preservative effect. (2), comprising 0.01 to 1.0% (w / v) 2-amino-3- (4-bromobenzoyl) phenylacetic acid or its salt, 215 to 360 mM borate ion and 0.001 to 0.15% (w / v) sodium edetate And is substantially free of a cationic preservative and a nonionic surfactant, and is an eyedrop having an osmotic pressure ratio of 0.8 to 1.3. In addition, it is also possible to use 0.01 to 1.0% (w / v) of 2-amino-3- (4-bromobenzoyl) phenylacetic acid or its salt, 215 to 360 mM borate ion and 0.001 to 0.15% Is an eye drop that contains sodium hydroxide and is substantially free of a cationic preservative and a nonionic surfactant and is an eye drop suitable for the criterion in the preservation efficacy test method of the Japanese Pharmacopoeia of the Sixteenth Amendment.
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