Metformin-comprising compositions for preventing or treating mitochondrial diseases caused by immunosuppressive drugs and immune diseases

摘要

The present invention compositions comprising metformin for mitochondrial diseases which are caused by that, more specifically, the immunosuppressive agent of the composition comprising metformin for the prophylaxis or treatment of mitochondrial diseases and autoimmune diseases which are caused by immunosuppressive agents, metformin and rapamycin target inhibitors (mTOR inhibitor) to the including pharmaceutical compositions and metformin and mammalian rapamycin target inhibitors for the prevention and treatment of autoimmune diseases comprising an immunosuppressant, as an active ingredient, as a component, and those at the same time or separately or in a predetermined sequence It relates to pharmaceutical combinations for the prevention and treatment of immune disorders which comprises administration. The compositions of the present invention is effectively mitigate mitochondrial function damage caused as a side effect of existing immunosuppressive agents, and are further enhanced immunosuppressive therapeutic effect, graft rejection requiring immunosuppression, autoimmune diseases, useful for preventing or treating inflammatory diseases, etc. it can be used.;