RE-IIBP RNF20 Method for screening therapeutic agents of hematological malignancies by interaction RE-IIBP with RNF20

摘要

The present invention is a RE-IIBP and RNF20 binding relates to a blood cancer screening method using the same, particularly to provide a blood cancer screening method comprises the step of screening the candidate drugs to promote bonding RE-IIBP and RNF20. On the other hand, the present inventors have determined that an increase in the degree hayeoteumeuro coupled RE-IIBP and RNF20 increase H3K79 HMTase activity of the RE-IIBP and, by stimulating the RE-IIBP- mediated transfer MEIS1 increase blood cancer cell death, the RE-IIBP and when combined RNF20 degree increase may be useful as a blood cancer screening method that increases the number of blood cancer cell death to treat blood cancers.;