12 Compositions for enhancing antitumor immunity comprising an oncolytic adenovirus co-expressing interleukin-12 and shVEGF

摘要

The present invention relates to a tumor-expressing adenovirus expressing both interleukin-12 and shVEGF, a composition for enhancing antitumor immunity comprising the same, and a composition for enhancing an anti-cancer effect. The present inventors have confirmed that, when immunoreactive mouse melanoma or kidney cancer model simultaneously exhibits VEGF inhibition and IL-12 expression, the immune function is restored and the anti-cancer effect is enhanced. In particular, the increased anticancer effect is associated with an increase in anti-cancer immunity, an increase in Th1 cytokine, and the prevention of tumor-induced thymic atrophy. Thus, the simultaneous expression of IL-12 and shVEGF The possibility of using the transporter was first identified.