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COMPOUND WITH AGONISTIC ACTIVITY AGAINST SOMATOSTATIN RECEPTORS AND ITS PHARMACEUTICAL APPLICATION

机译:具有抗生长抑素受体的活性的化合物及其药物应用

摘要

Provided is a somatostatin receptor subtype-2 agonist. A compound represented by general formula (I) [wherein each symbol has the same meaning as defined in the description], a salt thereof, an N-oxide thereof or a solvate thereof, or prodrugs of the same, which are low-molecular compounds having potent agonistic activity to somatostatin receptor subtype-2 and, therefore, can be administered in a simpler manner and have high safety and low toxicity, are useful in preventing and/or treating somatostatin-related diseases such as acromegaly and gastrointestinal obstruction.
机译:提供了一种生长抑素受体亚型2激动剂。通式(I)表示的化合物[其中每个符号具有与说明书中定义相同的含义],其盐,其N-氧化物或其溶剂化物或它们的前药,是低分子化合物对生长抑素受体亚型2具有有效的激动作用,因此可以简单的方式给药,安全性高,毒性低,可用于预防和/或治疗生长激素抑制素相关疾病,如肢端肥大症和胃肠道阻塞。

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