BIOMARKER MICRORNA FOR PREDICTION OF PROGNOSIS OF HEAD AND NECK CANCER

摘要

The present invention relates to a microRNA (hereinafter, referred to as "miRNA") capable of being used as a biomarker for the prediction of prognosis of head and neck cancer. More specifically, the purpose of the present invention is to perform the determination of a head and neck cancer subtype and the prediction of the prognosis thereof according to the expression level of miRNA selected from the group consisting of miR-206, miR-127-5p, miR-432-5p, miR-409-5p, miR-145-3p, miR-497-5p, miR-195-5p, miR-150-5p, miR-140-3p, miR-214-3p, miR-125b-5p, miR-99a-5p, miR-203a, miR-200a-5p, miR-200a-3p, miR-200b-5p, miR-200b-3p, miR-200c-3p, miR-141-3p, miR-205-5p, miR-183-5p, miR-106b-3p, miR-93-5p, miR-17-3p, miR-17-5p, miR-20a-5p, miR-92a-3p, miR-744-5p, miR-324-3p, miR-193a-5p, miR-149-5p, miR-1307-3p, miR-107, miR-103a-3p, miR-221-3p, miR222, miR-532-5p, miR-24-3p, miR-27b-5p, miR-27b-3p, and miR-23b-3p. The present invention is expected to provide a rapid and more accurate prognosis prediction and determination of a head and neck cancer subtype through the level of miRNA expression, and is expected to be greatly used in an effective head and neck cancer prognosis prediction method.