The present invention relates to an image sensor and to an X-ray system comprising such image sensor. More in particular, the invention relates to an image sensor wherein dose sensing pixels are used in conjunction with artificial pixels to sense a dose of incoming light or radiation.;According to the invention, the image sensor comprises one or more shielded photosensitive pixels that are shielded for incoming photons and which are each configured for outputting a further reference voltage, wherein the input voltage of the artificial pixels is set in dependence on the outputted further reference voltage(s).
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