SYSTEMS AND METHODS FOR EVALUATING PERTURBATION OF XENOBIOTIC METABOLISM

摘要

To provide systems and methods for evaluating perturbation of xenobiotic metabolism.SOLUTION: Systems and methods are provided for assessing perturbation of a target biological tissue caused by exposure to a factor. A set of scores that is indicative of a perturbation of target biological tissue in the xenobiotic metabolism of the target biological tissue and a surrogate biological tissue is determined based on a set of contrast data and a computational causal network model. The computational causal network model includes measurable nodes and backbone nodes connected by edges, the backbone nodes and measurable nodes each representing a biological activity related to xenobiotic metabolism. The edges represent causal relationships between connected nodes, where an activity value of a respective backbone node is determined by the activity evaluation criteria of the measurable nodes that are connected to the respective backbone node.SELECTED DRAWING: None