Method for reducing liver fibrosis based on ISHAK fibrosis stage in patients and method for treating lysosomal acid lipase deficiency

摘要

The present invention relates to a method of alleviating liver fibrosis in a human patient having a lysosomal acid lipase (LAL) deficiency comprising administering sevelipase alpha to the patient, wherein the patient is in the Ishak fibrosis stage. A method determined to have a reduction of at least 1 point (eg, a reduction of 1 point or more or a reduction of 2 points or more) after administration as compared to a baseline Ishak fibrosis stage obtained from the patient prior to administration I will provide a. A method of treating a human patient having a lysosomal acid lipase (LAL) deficiency comprising administering sevelipase alpha to the patient prior to administration at the Ishak fibrosis stage. A method is provided that has been determined to have at least a 1 point reduction (eg, a 1 point or more reduction or a 2 point or more reduction) after administration as compared to a baseline Ishak fibrosis stage obtained from [Selection figure] None