Standardized neuronal assay derived from primate species

摘要

This patent application relates to a method for generating a standardized robust neuronal cell culture assay from primate species, for example suitable for high-throughput screening of drug candidates. The method is based on a uniform NC based on differentiating human and / or non-human primate neural progenitor cells (NPC) into neural cells (NC) and dissociation and replating steps performed on differentiated NCs. Making the culture includes providing a robust culture suitable for high-throughput drug screening assays, particularly for screening antisense oligonucleotides.