Use of kaurane compounds in the manufacture of a medicament for the treatment of cardiac hypertrophy and pulmonary hypertension

摘要

The present invention relates to novel pharmaceutical uses of the Kaurane compounds of formula (I) in the treatment and prevention of cardiac hypertrophy and myocardial remodeling. The compounds can also significantly improve pulmonary hypertension and prevent vascular hypertrophy. The compounds inhibit fibrosis and treat erectile dysfunction, neurodegeneration and other related diseases by modulating cGMP or cAMP signaling pathways and / or reducing reactive oxygen species (ROS) It can also be used for Here, R 1 is hydrogen, hydroxyl or alkoxy. R2 contains carboxyl, carboxylate, acyl halide, aldehyde, methyl-hydroxyl, and ester, acylamide, hydrolysable acyl or ether group to carboxyl. R3, R4, R5, R6, R8 independently comprise an oxygen, hydroxyl, methyl-hydroxyl, and methyl-hydroxyl hydrolysable ester or alkoxymethyl group. R7 comprises methyl, hydroxyl and methyl-hydroxyl hydrolysable ester or alkoxymethyl. R9 contains methylene or oxygen.