(2R) -2- Off Le オ ロ -2-C- メ チ Le-D- リ ボ ノ-γ-ラ Network ト ン Class System make method

摘要

[Problem] To provide a method for producing a (2R)-2-fluoro-2-C-methyl-D-ribono--lactone. [Solution] A 2-fluoro-2-halopropionic acid derivative and a D-glyceraldehyde derivative are subjected to a Reformatsky reaction using an activated metal to produce various diastereomeric forms of a (2R)-2-fluoro-2-C-methyl-D-ribonono--lactone precursor. The resultant (2R)-2-fluoro-2-C-methyl-D-ribono--lactone precursor mixture is deprotected under acidic conditions, then lactonized to convert the mixture into a diastereomer mixture of 2-fluoro-2-C-methyl-D-ribono--lactone, and then recrystallized. In this manner, a (2R)-2-fluoro-2-C-methyl-D-ribono--lactone can be induced.