首页> 外国专利> Attenuated EHEC and clostridial toxins TcdA and TcdB based vaccine for Clostridium difficil associated disease (CDAD)

Attenuated EHEC and clostridial toxins TcdA and TcdB based vaccine for Clostridium difficil associated disease (CDAD)

机译：弱艰难梭菌和梭菌毒素TcdA和基于TcdB的艰难梭菌相关疾病（CDAD）疫苗

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摘要

Provided are novel methods for expressing antigens in a vaccine vector strain, a live oral vaccine designed to prevent clostridium difficile-associated disease and methods for delivering antigens to the mucosal immune system of a subject. 展开▼

机译：提供了用于在疫苗载体菌株中表达抗原的新颖方法，设计用于预防艰难梭菌相关疾病的活口服疫苗以及用于将抗原递送至受试者的粘膜免疫系统的方法。展开▼

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公开/公告号US10286054B2

专利类型

公开/公告日2019-05-14

原文格式PDF

申请/专利权人 DEPARTMENT OF VETERANS AFFAIRS;
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申请/专利号US201314435443

发明设计人 EDGAR C. BOEDEKER;SUDEEP KUMAR;
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申请日2013-10-11

分类号A61K39/08;C07K14/33;C12N15/70;A61K39;

国家 US

入库时间 2022-08-21 12:16:08

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1. 针对艰难梭菌的主要外毒素TcdA和TcdB的中和抗体 [P] . 中国专利： CN103958544B . 2018.04.24

2. 针对艰难梭菌的主要外毒素TcdA和TcdB的中和抗体 [P] . 中国专利： CN108424449A . 2018-08-21

3. AN ATTENUATED EHEC AND CLOSTRIDIAL TOXINS TCDA AND TCDB BASED VACCINE FOR CLOSTRIDIUM DIFFICIL ASSOCIATED DISEASE (CDAD) [P] . 美国专利： US2015343048A1 . 2015-12-03

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4. AN ATTENUATED EHEC AND CLOSTRIDIAL TOXINS TCDA AND TCDB BASED VACCINE FOR CLOSTRIDIUM DIFFICIL ASSOCIATED DISEASE (CDAD) [P] . 世界知识产权组织专利： WO2014059296A1 . 2014-04-17

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5. AN ATTENUATED EHEC AND CLOSTRIDIAL TOXINS TCDA AND TCDB BASED VACCINE FOR CLOSTRIDIUM DIFFICIL ASSOCIATED DISEASE (CDAD) [P] . 世界知识产权组织专利： WO2014059332A1 . 2014-04-17

机译：缓和的肠出血性和环孢毒素TCDA和TCDB疫苗，用于治疗与艰难梭菌相关的疾病（CDAD）

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