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Pro-drugs of riluzole and their method of use for the treatment of amyotrophic lateral sclerosis
Pro-drugs of riluzole and their method of use for the treatment of amyotrophic lateral sclerosis
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机译:利鲁唑的前药及其用于治疗肌萎缩性侧索硬化症的方法
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摘要
Pharmaceutical compositions of the invention include substituted riluzole pro drugs useful for the treatment of amyotrophic lateral sclerosis (ALS) and related disorders through the release of riluzole, especially to avoid patient to patient variability in first pass, hepatic metabolism promoted by Cyp 1A2. Pro-drugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process. The invention further includes pro-drugs of riluzole useful for the treatment of disease states that can be treated with riluzole through the release of riluzole from a pro-drug agent.
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