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C-Myc as a biomarker for tumor sensitivity to treatment with RNA polymerase II inhibition
C-Myc as a biomarker for tumor sensitivity to treatment with RNA polymerase II inhibition
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机译:C-Myc作为对RNA聚合酶II抑制治疗敏感性的生物标志物
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摘要
Systems and methods for determining whether a cancer patient may respond to inhibition of RNA polymerase II as a treatment for the patient are provided. Inhibition of RNA polymerase II may be by way of chemotherapy with an agent such as triptolide, an analog of triptolide, or a prodrug form of triptolide. The cancer patient may be a pancreatic cancer patient, an ovarian cancer patient, a gastric cancer patient, or an esophageal cancer patient. The patient may have any cancer in which c-Myc is over-expressed or over-amplified.
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