首页> 外国专利> Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using Apo A-I Milano gene transfer

Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using Apo A-I Milano gene transfer

机译:通过使用Apo A-I Milano基因转移调节单核细胞-巨噬细胞表型来抑制动脉粥样硬化

摘要

Embodiments of the present invention describe a method of changing the phenotype of monocytes and macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype. The method can comprises providing a composition comprising a recombinant adeno-associated virus (rAAV) vector comprising an exogenous gene encoding ApoA-I Milano or a fragment thereof, and administering the composition to a mammal in need thereof to change the phenotype of monocytes or macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype. By changing the phenotype of monocytes or macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype, atherosclerosis can be treated. The present invention also describes a method of monitoring macrophage phenotypic switching and a method of assessing the efficacy of the treatment of atherosclerosis.
机译:本发明的实施方案描述了一种将单核细胞和巨噬细胞的表型从促炎性M1表型改变为抗炎性M2表型的方法。该方法可以包括提供包含重组腺相关病毒(rAAV)载体的组合物,所述载体包含编码ApoA-I Milano或其片段的外源基因,并将该组合物施用于需要其的哺乳动物以改变单核细胞或巨噬细胞的表型。从促炎性M1型到抗炎性M2型。通过将单核细胞或巨噬细胞的表型从促炎性M1表型改变为抗炎性M2表型,可以治疗动脉粥样硬化。本发明还描述了监测巨噬细胞表型转换的方法和评估治疗动脉粥样硬化的功效的方法。

著录项

  • 公开/公告号US10391144B2

    专利类型

  • 公开/公告日2019-08-27

    原文格式PDF

  • 申请/专利权人 CEDARS-SINAI MEDICAL CENTER;

    申请/专利号US201816114635

  • 发明设计人 PREDIMAN K. SHAH;BEHROOZ SHARIFI;

    申请日2018-08-28

  • 分类号A61K48;A61K38/17;C07K14/775;C12Q1/686;

  • 国家 US

  • 入库时间 2022-08-21 12:15:14

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