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Stimulus-responsive poly(lactic-co-glycolic)-based polymers and nanoparticles formed therefrom
Stimulus-responsive poly(lactic-co-glycolic)-based polymers and nanoparticles formed therefrom
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机译:刺激响应的聚乳酸-乙醇酸共聚物型聚合物和由其形成的纳米颗粒
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摘要
PLGA-based polymers include pendant nucleophiles protected with photocleavable protecting groups. Upon deprotection, the polymers degrade rapidly via intramolecular cyclization into small molecules. The polymer may be formulated as a nanoparticle, with an encapsulated payload, which may be an imaging agent, a bioactive agent or a pharmaceutical agent.
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